5gms
 
Hordenine (N,N-Dimethyltyramine, Anhaline, peyocactine) is an all-natural extract from the Anhalonium fissuratum cactus plant that may have some nootropic benefits. It is used for:
Attention and alertness
Mood
Antibiotic and antimicrobial properties
Skin protection
Hordenine is naturally found in barley, and may be present in low levels in beer
What Does Hordenine Do?
Increases Alertness/Stimulant
Hordenine is such an effective stimulant that it is banned in horse racing
Hordenine is a known stimulant. It is actually effective enough that it is banned in horse racing.
It stimulates heart function, constricts blood vessels and relaxes bronchioles, making it a performance enhancing drug in this sport.2
Hordenine can increase the effect of norepinephrine by inhibiting MAO-B, which breaks it down.
Norepinepherine is a stimulatory transmitter that mobilizes the brain and body for action.
So, increasing levels of this hormone can have a definite stimulatory effect.3
One study shows that it “increases systolic and diastolic blood pressure, peripheral blood flow volume.”
It releases stored epinephrine vs stimulating new epinephrine to give a slight jolt.
Skin Protection
Hordenine can inhibit melanin production. Melanin is a necessary skin pigment, but when it is overproduced, it can cause skin issues like melasma or discoloration.
However, there is some evidence that hordenine can decrease melanin production by up to 30%.
 
How Hordenine Works In The Brain
 
Hordenine is a phenylethylamine alkaloid. Although researchers are not totally sure of it’s exact mechanism of action, it seems to work as a monoamine oxidase inhibitor.
Monoamine oxidase (MAO) is an enzyme that breaks down neurotransmitters like dopamine and epinephrine.
 
So, by inhibiting MAO, hordenine could raise overall levels of these neurotransmitters in the brain. This may be the reason for its effect on mood and motivation. 6
 
This mechanism of action means that hordenine may be most useful when combined with other nootropics.
For example, phenylethylamine (PEA) is a nootropic that can have great effects on cognition, but it is quickly broken down by MAO.
However, taking it with an MAO inhibitor like hordenine may help extend its effects.
Some users swear by the hordenine PEA stack, although it has not been studied clinically. There are also numerous reports of potentially dangerous side-effects (including addiction) from combining these two nootropics.
Hordenine also has antibacterial and antibiotic properties, and may be useful against staph infection in particular. 7
It can also reduce cAMP production, which in turn reduces melanin. This may have benefits for some skin issues. 8
How Much Hordenine Should I Take?
Standard dosage is about 20-50mg per day for humans.
Hordenine Potential Side Effects
Hordenine has not been studied on humans extensively, so its side effect profile is somewhat unknown.
Hordenine may have potentially serious side effects when taken with other medications due to its MAOI effects.
It may cause too many neurotransmitters to build up in the synapses, so consult your physician if you are on any medication.
Because it reduces melanin production, it may decrease UV protection.
 
phenylethylamine (PEA) is a nootropic and hordenine
 
PEA+Hordenine
Combining PEA with Hordenine can allow PEA to work more efficiently. After doing some research and trying a few different dosages, I feel comfortable with 300mg of PEA with 30mg of Hordenine. I am very wary of using much more than this and as it is effective for me, there is no need to try a higher dosage. I use this for added energy. I have also found that for some, myself included, this will temporarily relieve a stuffed up nose. I do not use it for the 10 minute feeling of euphoria that takes place about 20 minutes after ingesting, but for the pleasant and mood-lifting energy I get for a few hours after taking it. Some have noted that taking L-Tyrosine helps remove a crash feeling, but I haven't noticed any crash feeling, perhaps since I don't use too much. I have found that taking the Hordenine about 20 minutes prior to taking the PEA seems to be much more effective. I also usually take these on an empty stomach or close to empty stomach. I would recommend not taking a) too high a dosage; and b) too frequently. I have read that individuals may develop a tolerance to this, if used too frequently. I cycle this with other supplements about once a week or less.
 
 300mg (1/8th tsp)
 
PEA - feel good, do lot
To start, ive used PEA for about the past 8-10 months, normally only on weekends while playing games or watching movies. Taken in doses of 500mg-1.5g per dosage, every few hours, PEA provides the user a feeling of euphoria, energy, stimulation, and overall well being. Esp when combined with the mao-b inhibitor, hordenine, PEA takes on a whole new level of euphoria and overall happiness. If your a new user, start with 500mg doses, and dont freak if you experience red blotches or rashes, as they are only temp.
 
Fantastic Euphoria
I purchased P.E.A. along with the Hordenine I took a moderate does of both supplements and was blown away by the effects. I was not expecting such a rush of euphoria and I had to sit down because it was about to knock me on my butt. I did not intend for this to happen when taking this combination, but it was welcomed nonetheless. The euphoria lasted for about 20 minutes and after that I experienced several hours of wakefulness and clarity. I did not have any crash or comedown, I just seemed to return to baseline very naturally. Please research this combination if you attempt to do this for yourself. It can cause a dangerous rise in blood pressure and you might not like the results. Be careful as always.
 
Great product,
I had my doubts about the effectiveness of the pea/hordenine combination until I finally tried it. Do not underestimate this combo-it can produce powerful feelings of intense wellbeing so do your research and use prudence with the dose.
 
Actually works - which means it's probably dangerous. Don't take it if you are wimpy.
Yeah, this stimulant with the hordenine actually works very effectively unlike the green tea and other caffeine junk that just makes you feel horrible. The feeling from this combination is almost too good to be legal probably. I'm sure some idiot will overdose (probably a kid), die of a heart attack, the relatives will call the press, and it'll be illegal in a few years (as you know our society cannot handle true freedom so everything that hurts you, except guns, has to be illegal). Until that fateful day, though, this is a great legal high! It's not very long lasting, though, even with the hordenine. As with ANY stimulant, if you are some lard ass or have heart problems, DO NOT TAKE IT because it can kill you as it causes a blood pressure spike mostly because you are unhealthy.
 
Hordenine Safety
The average dose of hordenine is 25mg taken 3 times per day to maintain the effect. If adverse effects occur then reduce the dose or discontinue usage for a bit.
I find hordenine works nicely along side coffee or caffeine/theanine capsules to give them an added kick.
As mentioned earlier, Hordenine also goes nicely with Phenyethylamine as a preworkout before the gym.